Bedeutung der Androgenrezeptor-Spleißvariante AR-V7 für Prognose und Therapie des fortgeschrittenen Prostatakarzinoms

P Thelen, H Taubert, S Duensing, G Kristiansen, A S Merseburger, M V Cronauer


    A recently discovered mechanism enabling prostate cancer cells to escape the effects of endocrine therapies consists in the synthesis of C-terminally truncated, constitutively active androgen receptor (AR) splice variants (AR-V). Devoid of a functional C-terminal hormone/ligand binding domain, various AR-Vs are insensitive to therapies targeting the androgen/AR signalling axis. Preliminary studies suggest that AR-V7, the most common AR-V, is a promising predictive tumour marker and a relevant selection marker for the treatment of advanced prostate cancer. This review critically outlines recent advances in AR-V7 diagnostics and presents an overview of current AR-V7 targeted therapies.

    Titel in ÜbersetzungThe impact of the androgen receptor splice variant AR-V7 on the prognosis and treatment of advanced prostate cancer
    ZeitschriftAktuelle Urologie
    Seiten (von - bis)582-592
    PublikationsstatusVeröffentlicht - 2020

    Strategische Forschungsbereiche und Zentren

    • Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)