Abstract
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
Originalsprache | Englisch |
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Zeitschrift | Neurology |
Jahrgang | 65 |
Ausgabenummer | 11 |
Seiten (von - bis) | 1823-1825 |
Seitenumfang | 3 |
ISSN | 0028-3878 |
DOIs | |
Publikationsstatus | Veröffentlicht - 01.12.2005 |