Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Philipp H. Reichel; Christine Seemann; Elena Csernok; Jens M. Schröder; Antje Müller; Wolfgang L. Gross; Hendrik Schultz

doi:10.1128/CDLI.10.3.473-475.2003

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Philipp H. Reichel, Christine Seemann, Elena Csernok^*, Jens M. Schröder, Antje Müller, Wolfgang L. Gross, Hendrik Schultz

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Rheumatologie und klinische Immunologie

19 Zitate (Scopus)

Abstract

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

Originalsprache	Englisch
Zeitschrift	Clinical and Diagnostic Laboratory Immunology
Jahrgang	10
Ausgabenummer	3
Seiten (von - bis)	473-475
Seitenumfang	3
ISSN	1071-412X
DOIs	https://doi.org/10.1128/CDLI.10.3.473-475.2003
Publikationsstatus	Veröffentlicht - 06.2003

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Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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10.1128/CDLI.10.3.473-475.2003

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title = "Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4",

abstract = "The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.",

author = "Reichel, {Philipp H.} and Christine Seemann and Elena Csernok and Schr{\"o}der, {Jens M.} and Antje M{\"u}ller and Gross, {Wolfgang L.} and Hendrik Schultz",

year = "2003",

month = jun,

doi = "10.1128/CDLI.10.3.473-475.2003",

language = "English",

volume = "10",

pages = "473--475",

journal = "Clinical and Diagnostic Laboratory Immunology",

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Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4. / Reichel, Philipp H.; Seemann, Christine; Csernok, Elena et al.
in: Clinical and Diagnostic Laboratory Immunology, Jahrgang 10, Nr. 3, 06.2003, S. 473-475.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

AU - Reichel, Philipp H.

AU - Seemann, Christine

AU - Csernok, Elena

AU - Schröder, Jens M.

AU - Müller, Antje

AU - Gross, Wolfgang L.

AU - Schultz, Hendrik

PY - 2003/6

Y1 - 2003/6

N2 - The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

AB - The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gramnegative bacterial clearance and a dampened response to endotoxin in the skin.

UR - http://www.scopus.com/inward/record.url?scp=0037618998&partnerID=8YFLogxK

U2 - 10.1128/CDLI.10.3.473-475.2003

DO - 10.1128/CDLI.10.3.473-475.2003

M3 - Journal articles

C2 - 12738651

AN - SCOPUS:0037618998

SN - 1071-412X

VL - 10

SP - 473

EP - 475

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

IS - 3

ER -

Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4

Abstract

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