Autoreactive T cell responses in pemphigus and pemphigoid

Gertie J. Oostingh, Cassian Sitaru, Arno Kromminga, Dirk Dormann, Detlef Zillikens*

*Korrespondierende/r Autor/-in für diese Arbeit
13 Zitate (Scopus)

Abstract

Pemphigus and pemphigoid are cutaneous autoimmune diseases characterised by autoantibodies directed against specific adhesion proteins of the epidermis and dermal-epidermal junction. These proteins are usually associated with desmosomes or hemidesmosomes. Binding of antibodies to their targets leads to the loss of cell-cell or cell-matrix adhesion and subsequently to blister formation. The humoral aspects of the autoimmune responses in pemphigus and pemphigoid have been extensively studied in the past. More recently, the cellular interactions resulting in the formation of autoantibodies and the involvement of autoreactive T cells in these diseases have attracted increased interest. In this review, the current knowledge on T cell involvement in pemphigus and pemphigoid is summarised.

OriginalspracheEnglisch
ZeitschriftAutoimmunity Reviews
Jahrgang1
Ausgabenummer5
Seiten (von - bis)267-272
Seitenumfang6
ISSN1568-9972
DOIs
PublikationsstatusVeröffentlicht - 10.2002

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