Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function

Luciana Besedovsky; Hong Viet V. Ngo; Stoyan Dimitrov; Christoph Gassenmaier; Rainer Lehmann; Jan Born

doi:10.1038/s41467-017-02170-3

Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function

Luciana Besedovsky, Hong Viet V. Ngo, Stoyan Dimitrov, Christoph Gassenmaier, Rainer Lehmann, Jan Born^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Eberhard Karls Universität Tübingen

122 Zitate (Scopus)

Abstract

Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs. Stimulation intensifies the hormonal milieu characterizing SWS (mainly by further reducing cortisol and increasing aldosterone levels) and reduces T and B cell counts, likely reflecting a redistribution of these cells to lymphoid tissues. GH remains unchanged. In conclusion, closed-loop stimulation of SOs is an easy-to-use tool for probing SWS functions, and might also bear the potential to ameliorate conditions like depression and aging, where disturbed sleep coalesces with specific hormonal and immunological dysregulations.

Originalsprache	Englisch
Aufsatznummer	1984
Zeitschrift	Nature Communications
Jahrgang	8
Ausgabenummer	1
ISSN	1751-8628
DOIs	https://doi.org/10.1038/s41467-017-02170-3
Publikationsstatus	Veröffentlicht - 01.12.2017

Fördermittel

We are grateful to Ilja Goldins and Samuel Büttner for technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR-SFB 654) and from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (01GI0925).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

DFG-Fachsystematik

2.22-17 Endokrinologie, Diabetologie, Metabolismus

Dokumente

10.1038/s41467-017-02170-3

Weitere Links

Link to publication in Scopus

1 Abgeschlossen

SFB 654: Plastizität und Schlaf
Born, J. (Sprecher*in), Verleger, R. (Projektleiter*in (PI)), Witt, K. (Projektleiter*in (PI)), Gais, S. (Projektleiter*in (PI)), Kimmig, H. (Projektleiter*in (PI)), Backhaus, J. (Projektleiter*in (PI)), Junghanns, K. (Projektleiter*in (PI)), Marshall, L. (Projektleiter*in (PI)), Martinetz, T. (Projektleiter*in (PI)), Mölle, M. (Projektleiter*in (PI)), Deuschl, G. (Projektleiter*in (PI)), Mehdorn, H. M. (Projektleiter*in (PI)), Volkmann, J. (Projektleiter*in (PI)), Claussen, J. C. (Projektleiter*in (PI)), Göder, R. (Projektleiter*in (PI)), Anders, S. (Projektleiter*in (PI)), Binkofski, F. (Projektleiter*in (PI)), Büchel, C. (Projektleiter*in (PI)), Ehrlich, I. (Projektleiter*in (PI)), Baving, L. (Projektleiter*in (PI)), Prehn-Kristensen, A. (Projektleiter*in (PI)), Bartsch, T. (Projektleiter*in (PI)), Sirota, A. (Projektleiter*in (PI)), Münte, T. (Projektleiter*in (PI)), Heldmann, M. (Projektleiter*in (PI)), Diekelmann, S. (Projektleiter*in (PI)), Rauss, K. (Projektleiter*in (PI)), Sato, T. (Projektleiter*in (PI)), Krägeloh-Mann, I. (Projektleiter*in (PI)), Wilke, M. (Projektleiter*in (PI)), Hallschmid, M. (Projektleiter*in (PI)), Schmid, S. (Projektleiter*in (PI)), Kern, W. (Projektleiter*in (PI)), Perras, B. (Projektleiter*in (PI)), Poets, C. F. (Projektleiter*in (PI)), Sayk, F. (Projektleiter*in (PI)), Oster, H. (Projektleiter*in (PI)), Lehnert, H. (Projektleiter*in (PI)), Baier, P. C. (Projektleiter*in (PI)), Oltmanns, K. (Projektleiter*in (PI)), Fritsche, A. (Projektleiter*in (PI)), Preissl, H. (Projektleiter*in (PI)), Ernst, M. (Projektleiter*in (PI)), Zabel, P. (Projektleiter*in (PI)), Solbach, W. (Projektleiter*in (PI)), Kalies, K. (Projektleiter*in (PI)), Westermann, J. (Projektleiter*in (PI)), Rose-John, S. (Projektleiter*in (PI)), Lange, T. (Projektleiter*in (PI)), Rammensee, H. G. (Projektleiter*in (PI)), Autenrieth, S. E. (Projektleiter*in (PI)), Köhl, J. (Projektleiter*in (PI)) & Ehlers, M. (Projektleiter*in (PI))
01.01.05 → 31.12.17
Projekt: DFG Verbundprojekte › DFG Sonderforschungsbereiche / Transregios (SFB/TR)

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@article{3eedcd03395a42eab88a0d533daec166,

title = "Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function",

abstract = "Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs. Stimulation intensifies the hormonal milieu characterizing SWS (mainly by further reducing cortisol and increasing aldosterone levels) and reduces T and B cell counts, likely reflecting a redistribution of these cells to lymphoid tissues. GH remains unchanged. In conclusion, closed-loop stimulation of SOs is an easy-to-use tool for probing SWS functions, and might also bear the potential to ameliorate conditions like depression and aging, where disturbed sleep coalesces with specific hormonal and immunological dysregulations.",

author = "Luciana Besedovsky and Ngo, \{Hong Viet V.\} and Stoyan Dimitrov and Christoph Gassenmaier and Rainer Lehmann and Jan Born",

note = "Funding Information: We are grateful to Ilja Goldins and Samuel B{\"u}ttner for technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR-SFB 654) and from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (01GI0925). Publisher Copyright: {\textcopyright} 2017 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1038/s41467-017-02170-3",

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AU - Besedovsky, Luciana

AU - Ngo, Hong Viet V.

AU - Dimitrov, Stoyan

AU - Gassenmaier, Christoph

AU - Lehmann, Rainer

AU - Born, Jan

N1 - Funding Information: We are grateful to Ilja Goldins and Samuel Büttner for technical assistance. This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR-SFB 654) and from the German Federal Ministry of Education and Research to the German Center for Diabetes Research (01GI0925). Publisher Copyright: © 2017 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs. Stimulation intensifies the hormonal milieu characterizing SWS (mainly by further reducing cortisol and increasing aldosterone levels) and reduces T and B cell counts, likely reflecting a redistribution of these cells to lymphoid tissues. GH remains unchanged. In conclusion, closed-loop stimulation of SOs is an easy-to-use tool for probing SWS functions, and might also bear the potential to ameliorate conditions like depression and aging, where disturbed sleep coalesces with specific hormonal and immunological dysregulations.

AB - Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs. Stimulation intensifies the hormonal milieu characterizing SWS (mainly by further reducing cortisol and increasing aldosterone levels) and reduces T and B cell counts, likely reflecting a redistribution of these cells to lymphoid tissues. GH remains unchanged. In conclusion, closed-loop stimulation of SOs is an easy-to-use tool for probing SWS functions, and might also bear the potential to ameliorate conditions like depression and aging, where disturbed sleep coalesces with specific hormonal and immunological dysregulations.

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DO - 10.1038/s41467-017-02170-3

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VL - 8

JO - Nature Communications

JF - Nature Communications

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M1 - 1984

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Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function

Abstract

Fördermittel

UN SDGs

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

Dokumente

Weitere Links

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Projekte

SFB 654: Plastizität und Schlaf

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