Abstract
Objective: The nonsynonymous polymorphism rs763361 of the CD226 gene, which encodes DNAX accessory molecule 1, which is involved in T cell costimulation pathways, has recently been identified as a genetic risk factor for autoimmunity. The purpose of this study was to test for association of the CD226 rs763361 polymorphism with systemic sclerosis (SSc) in European Caucasian populations. Methods: CD226 rs763361 was genotyped in 3,632 individuals, consisting of a discovery sample (991 SSc patients and 1,008 controls) and a replication sample (999 SSc patients and 634 controls). All study subjects.
Originalsprache | Englisch |
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Zeitschrift | Arthritis and Rheumatism |
Jahrgang | 63 |
Ausgabenummer | 4 |
Seiten (von - bis) | 1097-1105 |
Seitenumfang | 9 |
ISSN | 0004-3591 |
DOIs | |
Publikationsstatus | Veröffentlicht - 04.2011 |
Strategische Forschungsbereiche und Zentren
- Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)