Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Sarah Doernberg; Bernhard Schaaf; Klaus Dalhoff; Lin Leng; Anna Beitin; Vincent Quagliarello; Richard Bucala

doi:10.1016/j.cyto.2010.12.010

Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Sarah Doernberg^*, Bernhard Schaaf, Klaus Dalhoff, Lin Leng, Anna Beitin, Vincent Quagliarello, Richard Bucala

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik III

Yale University

15 Zitate (Scopus)

Abstract

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

Originalsprache	Englisch
Zeitschrift	Cytokine
Jahrgang	53
Ausgabenummer	3
Seiten (von - bis)	292-294
Seitenumfang	3
ISSN	1043-4666
DOIs	https://doi.org/10.1016/j.cyto.2010.12.010
Publikationsstatus	Veröffentlicht - 01.03.2011

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10.1016/j.cyto.2010.12.010

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abstract = "Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.",

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AU - Quagliarello, Vincent

AU - Bucala, Richard

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AB - Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis.

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Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae

Abstract

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