Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study

Laura Schumann; Nora Eisemann; Jobst Augustin; Joachim Kieschke; Martin Meyer; Hiltraud Kajüter; Alexander Katalinic

doi:10.1111/ddg.15218

Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study

Laura Schumann, Nora Eisemann, Jobst Augustin, Joachim Kieschke, Martin Meyer, Hiltraud Kajüter, Alexander Katalinic

Abstract

BACKGROUND: Germany-wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early-stage melanoma incidence and melanoma mortality in subsequent years, using early-stage melanoma incidence as surrogate for screening participation and early detection.

PATIENTS AND METHODS: Data on melanoma incidence for 2005-2016 and melanoma mortality for 2005-2018 were obtained for 244 German counties. We investigated the correlation between several measures of incidence and mortality with correlation analyses and linear regressions.

RESULTS: Melanoma incidence of early stages (in situ and T1) rose by 69% between pre-screening (2005-2007) and screening period (2008-2010). In contrast, there was no temporal trend in mortality over time. Correlation coefficients between incidence and mortality variables ranged between -0.14 and 0.10 (not significant). Linear regression indicated that mortality 6 years after screening introduction decreases with increasing change in early-stage incidence (b = -0.0029, 95% confidence interval [-0.0066, 0.0007]).

CONCLUSIONS: The estimated population-based effects of skin cancer screening on melanoma mortality were minimal and not significant. A potential effectiveness cannot be demonstrated.

Originalsprache	Englisch
Zeitschrift	Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Jahrgang	21
Ausgabenummer	S5
Seiten (von - bis)	33-40
Seitenumfang	8
ISSN	1610-0379
DOIs	https://doi.org/10.1111/ddg.15218
Publikationsstatus	Veröffentlicht - 12.2023

Strategische Forschungsbereiche und Zentren

Profilbereich: Zentrum für Bevölkerungsmedizin und Versorgungsforschung (ZBV)
Profilbereich: Lübeck Integrated Oncology Network (LION)

DFG-Fachsystematik

2.22-02 Public Health, gesundheitsbezogene Versorgungsforschung, Sozial- und Arbeitsmedizin
2.22-14 Hämatologie, Onkologie

UN SDGs

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10.1111/ddg.15218

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Pertimo: Perspektiven einer multimodalen Evaluation der Hautkrebsfrüherkennung
Katalinic, A. (Projektleiter*in (PI)), Hübner, J. (Sprecher*in, Koordinator*in) & Heidenreich, A. (Beteiligte*r Wissenschaftler*in)
01.06.19 → 31.08.21
Projekt: Projekte aus Bundesmitteln › GBA-Projekte (Innovationsfonds)

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Schumann, L., Eisemann, N., Augustin, J., Kieschke, J., Meyer, M., Kajüter, H., & Katalinic, A. (2023). Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 21(S5), 33-40. https://doi.org/10.1111/ddg.15218

@article{55d787f437c84f61ae3a0082454a4435,

title = "Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study",

abstract = "BACKGROUND: Germany-wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early-stage melanoma incidence and melanoma mortality in subsequent years, using early-stage melanoma incidence as surrogate for screening participation and early detection.PATIENTS AND METHODS: Data on melanoma incidence for 2005-2016 and melanoma mortality for 2005-2018 were obtained for 244 German counties. We investigated the correlation between several measures of incidence and mortality with correlation analyses and linear regressions.RESULTS: Melanoma incidence of early stages (in situ and T1) rose by 69% between pre-screening (2005-2007) and screening period (2008-2010). In contrast, there was no temporal trend in mortality over time. Correlation coefficients between incidence and mortality variables ranged between -0.14 and 0.10 (not significant). Linear regression indicated that mortality 6 years after screening introduction decreases with increasing change in early-stage incidence (b = -0.0029, 95% confidence interval [-0.0066, 0.0007]).CONCLUSIONS: The estimated population-based effects of skin cancer screening on melanoma mortality were minimal and not significant. A potential effectiveness cannot be demonstrated.",

author = "Laura Schumann and Nora Eisemann and Jobst Augustin and Joachim Kieschke and Martin Meyer and Hiltraud Kaj{\"u}ter and Alexander Katalinic",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.",

year = "2023",

month = dec,

doi = "10.1111/ddg.15218",

language = "English",

volume = "21",

pages = "33--40",

journal = "Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG",

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Schumann, L , Eisemann, N, Augustin, J, Kieschke, J, Meyer, M, Kajüter, H & Katalinic, A 2023, 'Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study', Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Jg. 21, Nr. S5, S. 33-40. https://doi.org/10.1111/ddg.15218

Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study. / Schumann, Laura ; Eisemann, Nora; Augustin, Jobst et al.
in: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, Jahrgang 21, Nr. S5, 12.2023, S. 33-40.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study

AU - Schumann, Laura

AU - Eisemann, Nora

AU - Augustin, Jobst

AU - Kieschke, Joachim

AU - Meyer, Martin

AU - Kajüter, Hiltraud

AU - Katalinic, Alexander

PY - 2023/12

Y1 - 2023/12

N2 - BACKGROUND: Germany-wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early-stage melanoma incidence and melanoma mortality in subsequent years, using early-stage melanoma incidence as surrogate for screening participation and early detection.PATIENTS AND METHODS: Data on melanoma incidence for 2005-2016 and melanoma mortality for 2005-2018 were obtained for 244 German counties. We investigated the correlation between several measures of incidence and mortality with correlation analyses and linear regressions.RESULTS: Melanoma incidence of early stages (in situ and T1) rose by 69% between pre-screening (2005-2007) and screening period (2008-2010). In contrast, there was no temporal trend in mortality over time. Correlation coefficients between incidence and mortality variables ranged between -0.14 and 0.10 (not significant). Linear regression indicated that mortality 6 years after screening introduction decreases with increasing change in early-stage incidence (b = -0.0029, 95% confidence interval [-0.0066, 0.0007]).CONCLUSIONS: The estimated population-based effects of skin cancer screening on melanoma mortality were minimal and not significant. A potential effectiveness cannot be demonstrated.

AB - BACKGROUND: Germany-wide skin cancer screening was introduced in 2008 to reduce skin cancer mortality and morbidity. However, the effectiveness of the program is still unclear. We explore the relationship between early-stage melanoma incidence and melanoma mortality in subsequent years, using early-stage melanoma incidence as surrogate for screening participation and early detection.PATIENTS AND METHODS: Data on melanoma incidence for 2005-2016 and melanoma mortality for 2005-2018 were obtained for 244 German counties. We investigated the correlation between several measures of incidence and mortality with correlation analyses and linear regressions.RESULTS: Melanoma incidence of early stages (in situ and T1) rose by 69% between pre-screening (2005-2007) and screening period (2008-2010). In contrast, there was no temporal trend in mortality over time. Correlation coefficients between incidence and mortality variables ranged between -0.14 and 0.10 (not significant). Linear regression indicated that mortality 6 years after screening introduction decreases with increasing change in early-stage incidence (b = -0.0029, 95% confidence interval [-0.0066, 0.0007]).CONCLUSIONS: The estimated population-based effects of skin cancer screening on melanoma mortality were minimal and not significant. A potential effectiveness cannot be demonstrated.

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UR - https://www.mendeley.com/catalogue/928278fd-f802-3cf2-ba98-176606bbcdfc/

U2 - 10.1111/ddg.15218

DO - 10.1111/ddg.15218

M3 - Journal articles

C2 - 38063282

SN - 1610-0379

VL - 21

SP - 33

EP - 40

JO - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

IS - S5

ER -

Association of early-stage incidence and mortality in malignant melanoma - a population-based ecological study

Abstract

Strategische Forschungsbereiche und Zentren

DFG-Fachsystematik

UN SDGs

Zugriff auf Dokument

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Projekte

Pertimo: Perspektiven einer multimodalen Evaluation der Hautkrebsfrüherkennung

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