TY - JOUR
T1 - Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene
AU - Reich, Kristian
AU - Westphal, Götz
AU - König, Inke R.
AU - Mössner, Rotraut
AU - Krüger, Ullrich
AU - Ziegler, Andreas
AU - Neumann, Christine
AU - Schnuch, Axel
N1 - Funding Information:
Supported by the GEPA, Göttingen, Germany, and by the Deutsche Forschungsgemeinschaft.
PY - 2003/12
Y1 - 2003/12
N2 - Background: There is evidence that IL-16, a cytokine that induces chemotactic responses in CD4+ T cells, eosinophils, and dendritic cells, plays an important role during different types of cutaneous inflammatory responses, including allergic contact dermatitis (ACD) and atopic dermatitis (AD). Objectives: We sought to test for association between a promoter polymorphism in the IL16 gene (T to C transition at position -295) and ACD and AD, respectively. Methods: IL16 -295 genotypes were determined in samples from 2 separate case-control studies with white individuals. The first study included healthy individuals (n = 310) and patients with ACD (n = 86). These patients were polysensitized as defined by a contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen. The second study comprised healthy subjects (n = 214) and patients with AD (n = 94). Results: IL16 -295 genotypes were differently distributed among polysensitized and healthy control subjects (P = .0021). In particular, the IL16 -295*C/C genotype was overrepresented among polysensitized individuals (7.0% vs 1.0% in the control group; odds ratio, 7.68; 95% CI, 1.59-48.12). In contrast, there was no evidence for an association between the IL16 -295 polymorphism and AD. Conclusion: The IL16 -295 promoter polymorphism might influence susceptibility to contact allergy.
AB - Background: There is evidence that IL-16, a cytokine that induces chemotactic responses in CD4+ T cells, eosinophils, and dendritic cells, plays an important role during different types of cutaneous inflammatory responses, including allergic contact dermatitis (ACD) and atopic dermatitis (AD). Objectives: We sought to test for association between a promoter polymorphism in the IL16 gene (T to C transition at position -295) and ACD and AD, respectively. Methods: IL16 -295 genotypes were determined in samples from 2 separate case-control studies with white individuals. The first study included healthy individuals (n = 310) and patients with ACD (n = 86). These patients were polysensitized as defined by a contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen. The second study comprised healthy subjects (n = 214) and patients with AD (n = 94). Results: IL16 -295 genotypes were differently distributed among polysensitized and healthy control subjects (P = .0021). In particular, the IL16 -295*C/C genotype was overrepresented among polysensitized individuals (7.0% vs 1.0% in the control group; odds ratio, 7.68; 95% CI, 1.59-48.12). In contrast, there was no evidence for an association between the IL16 -295 polymorphism and AD. Conclusion: The IL16 -295 promoter polymorphism might influence susceptibility to contact allergy.
UR - http://www.scopus.com/inward/record.url?scp=0345733981&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2003.09.012
DO - 10.1016/j.jaci.2003.09.012
M3 - Journal articles
AN - SCOPUS:0345733981
SN - 0091-6749
VL - 112
SP - 1191
EP - 1194
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 6
ER -