Assessment of Reward-Related Brain Function After a Single Dose of Oxytocin in Autism: A Randomized Controlled Trial

Annalina V. Mayer*, Katrin Preckel, Kristin Ihle, Fabian A. Piecha, Klaus Junghanns, Stefan Reiche, Lena Rademacher, Laura Müller-Pinzler, David S. Stolz, Inge Kamp-Becker, Sanna Stroth, Stefan Roepke, Charlotte Küpper, Veronika Engert, Tania Singer, Philipp Kanske, Frieder M. Paulus, Sören Krach

*Korrespondierende/r Autor/-in für diese Arbeit
1 Zitat (Scopus)


Background: Autism spectrum disorder (ASD) is characterized by difficulties in social communication and interaction, which have been related to atypical neural processing of rewards, especially in the social domain. As intranasal oxytocin has been shown to modulate activation of the brain's reward circuit, oxytocin might ameliorate the processing of social rewards in ASD and thus improve social difficulties. Methods: In this randomized, double-blind, placebo-controlled, crossover functional magnetic resonance imaging study, we examined effects of a 24-IU dose of intranasal oxytocin on reward-related brain function in 37 men with ASD without intellectual impairment and 37 age- and IQ-matched control participants. Participants performed an incentive delay task that allows the investigation of neural activity associated with the anticipation and receipt of monetary and social rewards. Results: Nonsignificant tests suggested that oxytocin did not influence neural processes related to the anticipation of social or monetary rewards in either group. Complementary Bayesian analyses indicated moderate evidence for a null model, relative to an alternative model. Our results were inconclusive regarding possible oxytocin effects on amygdala responsiveness to social rewards during reward consumption. There were no significant differences in reward-related brain function between the two groups under placebo. Conclusions: Our results do not support the hypothesis that intranasal oxytocin generally enhances activation of reward-related neural circuits in men with and without ASD.

ZeitschriftBiological Psychiatry Global Open Science
Seiten (von - bis)136-146
PublikationsstatusVeröffentlicht - 04.2022

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)


  • 206-08 Kognitive und Systemische Humanneurowissenschaften