Antineutrophil cytoplasmic autoantibody testing in vasculitides

W. L. Gross*

*Korrespondierende/r Autor/-in für diese Arbeit
86 Zitate (Scopus)

Abstract

This article summarizes the most recent findings concerning the clinical relevance of antineutrophil cytoplasmic autoantibody (ANCA) testing for patients with idiopathic vasculitis and with diseases known to be associated with secondary vasculitis. The clinical value of granular cytoplasmic pattern (c)ANCA (proteinase 3 [PR3]-ANCA) and perinuclear fluorescence pattern (p)ANCA (myeloperoxidase [MPO]-ANCA) testing in Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA), respectively, is now well established; however, the various subspecificities beside myeloperoxidase (MPO), which also include the perinuclear staining pattern, are detectable not only in vasculitis, but equally in a heterogeneous patient population with a spectrum of autoimmune diseases and idiopathic chronic inflammatory diseases of the bowel, liver, and so forth. Future studies must establish the specificity, sensitivity, and role of these pANCA subspecificities usually measured by enzyme-linked immunosorbent assays for distinct disease entities in clinical medicine. In summary, despite the relatively poor understanding of the immunopathogenesis of ANCA-associated disease, cANCA (PR3-ANCA) and pANCA (MPO-ANCA) continue to be important clinical markers of the so-called 'ANCA-associated vasculitides' (i.e., WG, MPA, and Churg-Strauss syndrome).

OriginalspracheEnglisch
ZeitschriftRheumatic Disease Clinics of North America
Jahrgang21
Ausgabenummer4
Seiten (von - bis)987-1011
Seitenumfang25
ISSN0889-857X
PublikationsstatusVeröffentlicht - 1995

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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