Antibiotic resistance: Blocking tetracycline destruction

Sonja Petkovic; Winfried Hinrichs

doi:10.1038/nchembio.2396

Antibiotic resistance: Blocking tetracycline destruction

Sonja Petkovic, Winfried Hinrichs

Institut für Molekulare Medizin

Universität Greifswald

Abstract

Enzymology and structural and functional characterization of some FAD-dependent monooxygenases provide insights into degradation of tetracycline antibiotics, but also show unexpected features of substrate recognition, reaction mechanism, and competitive inhibition.

Originalsprache	Englisch
Zeitschrift	Nature Chemical Biology
Jahrgang	13
Ausgabenummer	7
Seiten (von - bis)	694-695
Seitenumfang	2
ISSN	1552-4450
DOIs	https://doi.org/10.1038/nchembio.2396
Publikationsstatus	Veröffentlicht - 01.07.2017

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10.1038/nchembio.2396

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Antibiotic resistance: Blocking tetracycline destruction

Abstract

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