TY - JOUR
T1 - Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
AU - Teruel, María
AU - Simeon, Carmen P.
AU - Broen, Jasper
AU - Vonk, Madelon C.
AU - Carreira, Patricia
AU - Camps, Maria T.
AU - García-Portales, Rosa
AU - Delgado-Frías, Esmeralda
AU - Gallego, Maria
AU - Espinosa, Gerard
AU - Beretta, Lorenzo
AU - Airó, Paolo
AU - Lunardi, Claudio
AU - Riemekasten, Gabriela
AU - Witte, Torsten
AU - Krieg, Thomas
AU - Kreuter, Alexander
AU - Distler, Jörg H.W.
AU - Hunzelmann, Nicolas
AU - Koeleman, Bobby P.
AU - Voskuyl, Alexandre E.
AU - Schuerwegh, Annemie J.
AU - González-Gay, Miguel T.
AU - Radstake, Timothy R.D.J.
AU - Martin, Javier
AU - Ortego-Centeno, Norberto
AU - Callejas, José Luis
AU - Ríos, Raquel
AU - Navarrete, Nuria
AU - Garcia, Antonio
AU - Fernández-Nebro, Antonio
AU - González-Escribano, María F.
AU - Sánchez-Román, Julio
AU - Castillo, M. Jesús
AU - Aguirre, M. Ángeles
AU - Gómez-Gracia, Inmaculada
AU - Fernández-Gutiérrez, Benjamín
AU - Rodríguez-Rodríguez, Luis
AU - Vicente, Esther
AU - Castro, Mónica Fernández
AU - Andreu, José Luis
AU - de la Peña, Paloma García
AU - López-Longo, Francisco Javier
AU - Martínez-Estupiñán, Lina
AU - Pros, Anna
AU - Fonollosa, Vicente
AU - Tolosa, Carlos
AU - Carballeira, Mónica Rodríguez
AU - Castellví, Ivan
AU - Narváez, Francisco Javier
AU - Blanco-García, Francisco Javier
AU - Oreiro, Natividad
AU - Robles, María Ángeles
AU - Egurbide, María Victoria
AU - SáezComet, Luis
AU - Blanco, Ricardo
AU - Díaz, Bernardino
AU - Trapiella, Luis
AU - Díaz, Federico
AU - Hernández, Vanesa
AU - Beltrán, Emma
AU - Román-Ivorra, José Andrés
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/6/25
Y1 - 2012/6/25
N2 - Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.
AB - Introduction: The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).Methods: In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.Results: No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.Conclusions: Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc.
UR - http://www.scopus.com/inward/record.url?scp=84862597986&partnerID=8YFLogxK
U2 - 10.1186/ar3890
DO - 10.1186/ar3890
M3 - Journal articles
C2 - 22731751
AN - SCOPUS:84862597986
SN - 1478-6354
VL - 14
JO - Arthritis Research and Therapy
JF - Arthritis Research and Therapy
IS - 3
M1 - R154
ER -
