Alterations in the phenotype of CMV-specific and total CD8
                        +
                         T-cell populations in Wegener's granulomatosis

Peter Lamprecht; Ana L. Vargas Cuero; Antje Muller; Elena Csernok; Jan Voswinkel; Matthias Maass; Werner Solbach; Wolfgang L. Gross; Paul Klenerman

doi:10.1016/j.cellimm.2003.08.003

Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis

Peter Lamprecht^*, Ana L. Vargas Cuero, Antje Muller, Elena Csernok, Jan Voswinkel, Matthias Maass, Werner Solbach, Wolfgang L. Gross, Paul Klenerman

^*Korrespondierende/r Autor/-in für diese Arbeit

Klinik für Rheumatologie und klinische Immunologie

13 Zitate (Scopus)

Abstract

Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 ⁺ tet(ramer) ⁺ T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 ⁺ tet ^- T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 ⁺ T-cell compartment also affecting virus-specific T-cell responses in WG.

Originalsprache	Englisch
Zeitschrift	Cellular Immunology
Jahrgang	224
Ausgabenummer	1
Seiten (von - bis)	1-7
Seitenumfang	7
ISSN	0008-8749
DOIs	https://doi.org/10.1016/j.cellimm.2003.08.003
Publikationsstatus	Veröffentlicht - 01.01.2003

Fördermittel

Supported by Grants SFB367/A8 (P.L., A.M., W.L.G.), SFB367/A11 (J.V.) and SFB367/B11 (M.M.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M., P.L.), Welcome trust and the Medical Research Council, UK (P.K.).

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

Dokumente

10.1016/j.cellimm.2003.08.003

Weitere Links

Link to publication in Scopus

Zitieren

Lamprecht, P., Vargas Cuero, A. L., Muller, A., Csernok, E., Voswinkel, J., Maass, M., Solbach, W., Gross, W. L., & Klenerman, P. (2003). Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis. Cellular Immunology, 224(1), 1-7. https://doi.org/10.1016/j.cellimm.2003.08.003

@article{d6e0def7133c49a0ae5ed0edcd1a6be3,

title = "Alterations in the phenotype of CMV-specific and total CD8 + T-cell populations in Wegener's granulomatosis",

abstract = " Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 + tet(ramer) + T-cells in WG. A marked proportion of these cells displayed a late differentiated {"}effector memory{"} T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 + tet - T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 + T-cell compartment also affecting virus-specific T-cell responses in WG.",

author = "Peter Lamprecht and \{Vargas Cuero\}, \{Ana L.\} and Antje Muller and Elena Csernok and Jan Voswinkel and Matthias Maass and Werner Solbach and Gross, \{Wolfgang L.\} and Paul Klenerman",

year = "2003",

month = jan,

day = "1",

doi = "10.1016/j.cellimm.2003.08.003",

language = "English",

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Lamprecht, P, Vargas Cuero, AL, Muller, A, Csernok, E, Voswinkel, J, Maass, M, Solbach, W, Gross, WL & Klenerman, P 2003, 'Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis', Cellular Immunology, Jg. 224, Nr. 1, S. 1-7. https://doi.org/10.1016/j.cellimm.2003.08.003

Alterations in the phenotype of CMV-specific and total CD8 ⁺ T-cell populations in Wegener's granulomatosis. / Lamprecht, Peter; Vargas Cuero, Ana L.; Muller, Antje et al.
in: Cellular Immunology, Jahrgang 224, Nr. 1, 01.01.2003, S. 1-7.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Alterations in the phenotype of CMV-specific and total CD8 + T-cell populations in Wegener's granulomatosis

AU - Lamprecht, Peter

AU - Vargas Cuero, Ana L.

AU - Muller, Antje

AU - Csernok, Elena

AU - Voswinkel, Jan

AU - Maass, Matthias

AU - Solbach, Werner

AU - Gross, Wolfgang L.

AU - Klenerman, Paul

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 + tet(ramer) + T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 + tet - T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 + T-cell compartment also affecting virus-specific T-cell responses in WG.

AB - Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8 + tet(ramer) + T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8 + tet - T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8 + T-cell compartment also affecting virus-specific T-cell responses in WG.

UR - https://www.scopus.com/pages/publications/0142200378

U2 - 10.1016/j.cellimm.2003.08.003

DO - 10.1016/j.cellimm.2003.08.003

M3 - Journal articles

C2 - 14572795

AN - SCOPUS:0142200378

SN - 0008-8749

VL - 224

SP - 1

EP - 7

JO - Cellular Immunology

JF - Cellular Immunology

IS - 1

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Alterations in the phenotype of CMV-specific and total CD8 + T-cell populations in Wegener's granulomatosis