Allele frequencies of dna markers genetically linked to friedreich ataxia in the german population

Christine Zühlke*, Ulrike Thies

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Friedreich ataxia (FRDA) is a recessive neurodegenerative disorder affecting both central and peripheral nervous systems. The mutation was mapped to chromosome 9 by its tight linkage to the polymorphic loci D9S5 and D9S15. Using informative DNA markers the allele frequencies at these loci, in up to 84 unrelated healthy persons and in 16 FRDA patients of German origin, were determined. The comparison to data from other European populations did not reveal remarkable differences. No significant linkage disequilibrium could be observed between FRDA and the loci D9S5 and D9S15 in German families.

OriginalspracheEnglisch
ZeitschriftHuman Heredity
Jahrgang43
Ausgabenummer2
Seiten (von - bis)78-81
Seitenumfang4
ISSN0001-5652
DOIs
PublikationsstatusVeröffentlicht - 1993

Strategische Forschungsbereiche und Zentren

  • Querschnittsbereich: Medizinische Genetik

Fingerprint

Untersuchen Sie die Forschungsthemen von „Allele frequencies of dna markers genetically linked to friedreich ataxia in the german population“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren