All-cause mortality and serum insulin-like growth factor I in primary care patients

N. Friedrich; H. Schneider; M. Dörr; M. Nauck; H. Völzke; J. Klotsche; C. Sievers; D. Pittrow; S. Böhler; H. Lehnert; L. Pieper; H. U. Wittchen; H. Wallaschofski; G. K. Stalla

doi:10.1016/j.ghir.2011.02.003

All-cause mortality and serum insulin-like growth factor I in primary care patients

N. Friedrich^*, H. Schneider, M. Dörr, M. Nauck, H. Völzke, J. Klotsche, C. Sievers, D. Pittrow, S. Böhler, H. Lehnert, L. Pieper, H. U. Wittchen, H. Wallaschofski, G. K. Stalla

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik I

15 Zitate (Scopus)

Abstract

Objective: Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Design: DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles. Results: Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95% confidence interval [CI] 1.05-2.73), p = 0.03] and high [HR 1.76 (95% CI 1.09-2.85), p = 0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women. Conclusions: The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.

Originalsprache	Englisch
Zeitschrift	Growth Hormone and IGF Research
Jahrgang	21
Ausgabenummer	2
Seiten (von - bis)	102-106
Seitenumfang	5
ISSN	1096-6374
DOIs	https://doi.org/10.1016/j.ghir.2011.02.003
Publikationsstatus	Veröffentlicht - 01.04.2011

Fördermittel

Diabetes cardiovascular risk-evaluation: targets and essential data for commitment of treatment (DETECT) is a cross-sectional and prospective-longitudinal, nationwide clinical epidemiological study. Principal investigator: Prof. Dr. H.-U. Wittchen; Staff members: Dipl.-Psych. L. Pieper, Dipl.-Math. J. Klotsche, Dipl.-Psych. T. Eichler, Dr. H. Glaesmer, E. Katze, Dipl.-Psych. A. Bayer, Dipl.-Psych. A. Neumann. Steering Committee: Prof. Dr. H. Lehnert (Magdeburg, Coventry), Prof. Dr. G.K. Stalla (Munich), Prof. Dr. M.A. Zeiher (Frankfurt); Advisory Board: Prof. Dr. W. März (Graz/Heidelberg), Prof. Dr. S. Silber (Munich), Prof. Dr. Dr. U. Koch (Hamburg), PD Dr. D. Pittrow (Munich, Dresden), and Professor Dr. M. Wehling (Mannheim). This work is part of the research project Greifswald Approach to Individualized Medicine (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of Education and Research and the Ministry of Cultural Affairs of the Federal State of Mecklenburg — West Pomerania ( 03IS2061A ).

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10.1016/j.ghir.2011.02.003

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Friedrich, N., Schneider, H., Dörr, M., Nauck, M., Völzke, H., Klotsche, J., Sievers, C., Pittrow, D., Böhler, S., Lehnert, H., Pieper, L., Wittchen, H. U., Wallaschofski, H., & Stalla, G. K. (2011). All-cause mortality and serum insulin-like growth factor I in primary care patients. Growth Hormone and IGF Research, 21(2), 102-106. https://doi.org/10.1016/j.ghir.2011.02.003

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title = "All-cause mortality and serum insulin-like growth factor I in primary care patients",

abstract = "Objective: Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Design: DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles. Results: Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95\% confidence interval [CI] 1.05-2.73), p = 0.03] and high [HR 1.76 (95\% CI 1.09-2.85), p = 0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women. Conclusions: The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.",

author = "N. Friedrich and H. Schneider and M. D{\"o}rr and M. Nauck and H. V{\"o}lzke and J. Klotsche and C. Sievers and D. Pittrow and S. B{\"o}hler and H. Lehnert and L. Pieper and Wittchen, \{H. U.\} and H. Wallaschofski and Stalla, \{G. K.\}",

year = "2011",

month = apr,

day = "1",

doi = "10.1016/j.ghir.2011.02.003",

language = "English",

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journal = "Growth Hormone and IGF Research",

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Friedrich, N, Schneider, H, Dörr, M, Nauck, M, Völzke, H, Klotsche, J, Sievers, C, Pittrow, D, Böhler, S, Lehnert, H, Pieper, L, Wittchen, HU, Wallaschofski, H & Stalla, GK 2011, 'All-cause mortality and serum insulin-like growth factor I in primary care patients', Growth Hormone and IGF Research, Jg. 21, Nr. 2, S. 102-106. https://doi.org/10.1016/j.ghir.2011.02.003

TY - JOUR

T1 - All-cause mortality and serum insulin-like growth factor I in primary care patients

AU - Friedrich, N.

AU - Schneider, H.

AU - Dörr, M.

AU - Nauck, M.

AU - Völzke, H.

AU - Klotsche, J.

AU - Sievers, C.

AU - Pittrow, D.

AU - Böhler, S.

AU - Lehnert, H.

AU - Pieper, L.

AU - Wittchen, H. U.

AU - Wallaschofski, H.

AU - Stalla, G. K.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Objective: Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Design: DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles. Results: Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95% confidence interval [CI] 1.05-2.73), p = 0.03] and high [HR 1.76 (95% CI 1.09-2.85), p = 0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women. Conclusions: The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.

AB - Objective: Previous population-based studies provided conflicting results regarding the association of total serum insulin-like growth factor I (IGF-I) and mortality. The aim of the present study was to assess the relation of IGF-I levels with all-cause mortality in a prospective study. Design: DETECT (Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment) is a large, multistage, and nationally representative study of primary care patients in Germany. The study population included 2463 men and 3603 women. Death rates were recorded by the respective primary care physician. Serum total IGF-I levels were determined by chemiluminescence immunoassays and categorized into three groups (low, moderate, and high) according to the sex- and age-specific 10th and 90th percentiles. Results: Adjusted analyses revealed that men with low [hazard ratio (HR) 1.70 (95% confidence interval [CI] 1.05-2.73), p = 0.03] and high [HR 1.76 (95% CI 1.09-2.85), p = 0.02] IGF-I levels had higher risk of all-cause mortality compared to men with moderate IGF-I levels. The specificity of low IGF-I and high IGF-I levels increased with lower and higher cut-offs, respectively. No such association became apparent in women. Conclusions: The present study revealed a U-shaped relation between IGF-I and all-cause mortality in male primary care patients.

UR - https://www.scopus.com/pages/publications/79955479312

U2 - 10.1016/j.ghir.2011.02.003

DO - 10.1016/j.ghir.2011.02.003

M3 - Journal articles

C2 - 21435927

AN - SCOPUS:79955479312

SN - 1096-6374

VL - 21

SP - 102

EP - 106

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

IS - 2

ER -

All-cause mortality and serum insulin-like growth factor I in primary care patients

Abstract

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