Alcoholism, craving, and hormones: The role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake

Friedrich Martin Wurst*, Dennis D. Rasmussen, Thomas Hillemacher, Thomas Kraus, Katrin Ramskogler, Otto Lesch, Kristina Bayerlein, Anja Schanze, Julia Wilhelm, Klaus Junghanns, Tilman Schulte, Gerhard Dammann, Lutz Pridzun, Gerhard Wiesbeck, Johannes Kornhuber, Stefan Bleich

*Korrespondierende/r Autor/-in für diese Arbeit
    32 Zitate (Scopus)

    Abstract

    Evidence is growing that appetite regulating peptides such as leptin and ghrelin, but also other hormones including prolactin are altered in alcoholism. The brain pro-opiomelanocortin (POMC) system which has important mediating roles in alcohol intake also has important functions in prolactin regulation and energy homeostasis. Furthermore, it has been demonstrated to be functionally integrated with leptin regulation. The satiety factor leptin seems to be counteracted by the gut-derived peptide ghrelin which increases hunger and food intake. Consequently, the POMC system may have a role in integrating regulation of alcohol effects and these seemingly disparate regulatory systems. The goal of this mini-review is to discuss the results of some recent investigations of the potential interactions of these systems with acute and chronic alcohol responses.

    OriginalspracheEnglisch
    ZeitschriftAlcoholism: Clinical and Experimental Research
    Jahrgang31
    Ausgabenummer12
    Seiten (von - bis)1963-1967
    Seitenumfang5
    ISSN0145-6008
    DOIs
    PublikationsstatusVeröffentlicht - 12.2007

    Strategische Forschungsbereiche und Zentren

    • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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