Abstract
Adrenal insufficiency is a rare disease with an estimated prevalence of 100–126 cases per million for primary adrenal insufficiency (PAI) and 450 cases per million for secondary/tertiary adrenal insufficiency (SAI/TAI) [1, 2]. Glucocorticoid replacement therapy (GRT) is the gold standard and only viable treatment for AI [3]. The present guideline on PAI recommends the use of hydrocortisone (HC) or prednisolone for GRT [3]. However, currently used GRT regimens inadequately mimic the physiological rhythm of endogenous cortisol secretion leading to temporary hypercortisolism and hypocortisolism [4]. The consequences of these conditions are not completely understood but may be associated with deleterious effects on body composition [5]. In fact, patients with AI on GRT have an increased cardiovascular and cerebrovascular mortality [6, 7].
Since inflammation is known to have a role in the pathogenesis of cardiovascular diseases, measurement of inflammatory markers has been suggested for...
Since inflammation is known to have a role in the pathogenesis of cardiovascular diseases, measurement of inflammatory markers has been suggested for...
Originalsprache | Englisch |
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Zeitschrift | Endocrine |
Jahrgang | 64 |
Ausgabenummer | 3 |
Seiten (von - bis) | 727-729 |
Seitenumfang | 3 |
ISSN | 1355-008X |
DOIs |
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Publikationsstatus | Veröffentlicht - 15.06.2019 |
Strategische Forschungsbereiche und Zentren
- Zentren: Universitäres Herzzentrum Lübeck (UHZL)
DFG-Fachsystematik
- 2.22-12 Kardiologie, Angiologie