Adrenal insufficiency treated with conventional hydrocortisone leads to elevated levels of Interleukin-6: a pilot study

Amir Hossein Rahvar*, Martin Riesel, Tobias Graf, Birgit Harbeck

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Adrenal insufficiency is a rare disease with an estimated prevalence of 100–126 cases per million for primary adrenal insufficiency (PAI) and 450 cases per million for secondary/tertiary adrenal insufficiency (SAI/TAI) [1, 2]. Glucocorticoid replacement therapy (GRT) is the gold standard and only viable treatment for AI [3]. The present guideline on PAI recommends the use of hydrocortisone (HC) or prednisolone for GRT [3]. However, currently used GRT regimens inadequately mimic the physiological rhythm of endogenous cortisol secretion leading to temporary hypercortisolism and hypocortisolism [4]. The consequences of these conditions are not completely understood but may be associated with deleterious effects on body composition [5]. In fact, patients with AI on GRT have an increased cardiovascular and cerebrovascular mortality [6, 7].

Since inflammation is known to have a role in the pathogenesis of cardiovascular diseases, measurement of inflammatory markers has been suggested for...

OriginalspracheEnglisch
ZeitschriftEndocrine
Jahrgang64
Ausgabenummer3
Seiten (von - bis)727-729
Seitenumfang3
ISSN1355-008X
DOIs
PublikationsstatusVeröffentlicht - 15.06.2019

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Herzzentrum Lübeck (UHZL)

DFG-Fachsystematik

  • 2.22-12 Kardiologie, Angiologie

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