Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

Felicitas Rombold; Eric Lauterbach; Werner Felber; Bruno Mueller-Oerlinghausen; Bernd Ahrens; Thomas Bronisch; Birgit Kilb; Ute Lewitzka; Kneginja Richter; Andreas Broocks; Isabella Heuser; Fritz Hohagen; Arnim Quante

doi:10.3109/13651501.2014.940052

Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

Felicitas Rombold, Eric Lauterbach, Werner Felber, Bruno Mueller-Oerlinghausen, Bernd Ahrens, Thomas Bronisch, Birgit Kilb, Ute Lewitzka, Kneginja Richter, Andreas Broocks, Isabella Heuser, Fritz Hohagen, Arnim Quante^*

^*Korrespondierende/r Autor/-in für diese Arbeit

7 Zitate (Scopus)

Abstract

Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet.

Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted.

Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention.

Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.

Originalsprache	Englisch
Zeitschrift	International Journal of Psychiatry in Clinical Practice
Jahrgang	18
Ausgabenummer	4
Seiten (von - bis)	300-303
Seitenumfang	4
ISSN	1365-1501
DOIs	https://doi.org/10.3109/13651501.2014.940052
Publikationsstatus	Veröffentlicht - 01.10.2014

Strategische Forschungsbereiche und Zentren

Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.3109/13651501.2014.940052

Andere Dateien und Links

Link to publication in Scopus

Zitieren

Rombold, F., Lauterbach, E., Felber, W., Mueller-Oerlinghausen, B., Ahrens, B., Bronisch, T., Kilb, B., Lewitzka, U., Richter, K., Broocks, A., Heuser, I., Hohagen, F., & Quante, A. (2014). Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders. International Journal of Psychiatry in Clinical Practice, 18(4), 300-303. https://doi.org/10.3109/13651501.2014.940052

@article{49355b39dadf4f8b915bd40cbeeec077,

title = "Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders",

abstract = "Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet.Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted.Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention.Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.",

author = "Felicitas Rombold and Eric Lauterbach and Werner Felber and Bruno Mueller-Oerlinghausen and Bernd Ahrens and Thomas Bronisch and Birgit Kilb and Ute Lewitzka and Kneginja Richter and Andreas Broocks and Isabella Heuser and Fritz Hohagen and Arnim Quante",

note = "Publisher Copyright: {\textcopyright} 2014 Informa Healthcare.",

year = "2014",

month = oct,

day = "1",

doi = "10.3109/13651501.2014.940052",

language = "English",

volume = "18",

pages = "300--303",

journal = "International Journal of Psychiatry in Clinical Practice",

issn = "1365-1501",

number = "4",

}

Rombold, F, Lauterbach, E, Felber, W, Mueller-Oerlinghausen, B, Ahrens, B, Bronisch, T, Kilb, B, Lewitzka, U, Richter, K, Broocks, A, Heuser, I, Hohagen, F & Quante, A 2014, 'Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders', International Journal of Psychiatry in Clinical Practice, Jg. 18, Nr. 4, S. 300-303. https://doi.org/10.3109/13651501.2014.940052

Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders. / Rombold, Felicitas; Lauterbach, Eric; Felber, Werner et al.
in: International Journal of Psychiatry in Clinical Practice, Jahrgang 18, Nr. 4, 01.10.2014, S. 300-303.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

AU - Rombold, Felicitas

AU - Lauterbach, Eric

AU - Felber, Werner

AU - Mueller-Oerlinghausen, Bruno

AU - Ahrens, Bernd

AU - Bronisch, Thomas

AU - Kilb, Birgit

AU - Lewitzka, Ute

AU - Richter, Kneginja

AU - Broocks, Andreas

AU - Heuser, Isabella

AU - Hohagen, Fritz

AU - Quante, Arnim

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet.Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted.Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention.Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.

AB - Objective. Patients with both major depression and personality disorders have a high risk of suicidal behavior. Lithium is meant to have anti-suicidal properties in patients with affective disorders. The anti-suicidal effect of lithium in patients with affective disorders and comorbid personality disorders has not been investigated yet.Methods. A post-hoc analysis of a subsample of patients with depression and comorbid personality disorder (PD) and a recent suicide attempt (n = 19) from the prospective, placebo-controlled lithium intervention study (N = 167), was conducted.Results. Three patients in the lithium group (n = 8) and two patients in the placebo group (n = 11) presented a suicide attempt throughout the course of the study. No differences related to suicidal behavior could be detected between the placebo group and the group with lithium intervention.Conclusions. On the basis of the small sample size, among patients with comorbid PD, lithium does not seem to have an effect on suicidal behavior in contrast to patients with affective disorders without comorbid PD.

UR - http://www.scopus.com/inward/record.url?scp=84910055850&partnerID=8YFLogxK

U2 - 10.3109/13651501.2014.940052

DO - 10.3109/13651501.2014.940052

M3 - Journal articles

C2 - 24994476

AN - SCOPUS:84910055850

SN - 1365-1501

VL - 18

SP - 300

EP - 303

JO - International Journal of Psychiatry in Clinical Practice

JF - International Journal of Psychiatry in Clinical Practice

IS - 4

ER -

Adjunctive lithium treatment in the prevention of suicidal behavior in patients with depression and comorbid personality disorders

Abstract

Strategische Forschungsbereiche und Zentren

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Zitieren