Adipose tissue as source and target for novel therapies

Johannes Klein; Nina Perwitz; Daniel Kraus; Mathias Fasshauer

doi:10.1016/j.tem.2005.11.008

Adipose tissue as source and target for novel therapies

Johannes Klein^*, Nina Perwitz, Daniel Kraus, Mathias Fasshauer

^*Korrespondierende/r Autor/-in für diese Arbeit

Medizinische Klinik I

Universität Leipzig

48 Zitate (Scopus)

Abstract

The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

Originalsprache	Englisch
Zeitschrift	Trends in Endocrinology and Metabolism
Jahrgang	17
Ausgabenummer	1
Seiten (von - bis)	26-32
Seitenumfang	7
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2005.11.008
Publikationsstatus	Veröffentlicht - 01.01.2006

Fördermittel

J.K. is a Feodor-Lynen fellow of the Alexander von Humboldt Foundation. This work was supported by the Deutsche Forschungsgemeinschaft. AdipoR: adiponectin receptor aP2: fatty acid binding protein AMPK: AMP-activated protein kinase AR: angiotensin receptor ATGL: adipose triglyceride lipase CNTF: ciliary neurotrophic factor EC: endocannabinoid FATP: fatty acid transporter protein GIP: glucose-dependent insulinotropic polypeptide 11β-HSD-1: 11β-hydroxy steroid dehydrogenase-1 HSL: hormone sensitive lipase IL-6: Interleukin-6 IRS: insulin receptor substrate-1 PGC1α: PPARγ coactivator 1 α PPAR: peroxisome proliferator-activated receptor PAI-1: plasminogen activator inhibitor-1 RAS: renin angiotensin system RBP4: retinol-binding protein 4 RXRα: retinoid X receptor α SRC1: steroid receptor coactivator 1 SRM: steroid receptor modulator TNF-α: tumour necrosis factor α TZDs: thiazolidinediones TIF2: transcription intermediary factor 2

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Dokumente

10.1016/j.tem.2005.11.008

Weitere Links

Link to publication in Scopus

Zitieren

@article{c1aac165afb84a909de2042562897250,

title = "Adipose tissue as source and target for novel therapies",

abstract = "The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.",

author = "Johannes Klein and Nina Perwitz and Daniel Kraus and Mathias Fasshauer",

year = "2006",

month = jan,

day = "1",

doi = "10.1016/j.tem.2005.11.008",

language = "English",

volume = "17",

pages = "26--32",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Adipose tissue as source and target for novel therapies

AU - Klein, Johannes

AU - Perwitz, Nina

AU - Kraus, Daniel

AU - Fasshauer, Mathias

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

AB - The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/ thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

UR - https://www.scopus.com/pages/publications/29744458790

U2 - 10.1016/j.tem.2005.11.008

DO - 10.1016/j.tem.2005.11.008

M3 - Scientific review articles

C2 - 16309918

AN - SCOPUS:29744458790

SN - 1043-2760

VL - 17

SP - 26

EP - 32

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 1

ER -

Adipose tissue as source and target for novel therapies

Abstract

Fördermittel

UN SDGs

Dokumente

Weitere Links

Fingerprint

Zitieren