Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia

Kensuke Shima; Matthias Klinger; Werner Solbach; Jan Rupp

doi:10.1128/AAC.02211-12

Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia

Kensuke Shima, Matthias Klinger, Werner Solbach, Jan Rupp

Institut für Chemie und Metabolomics

Abstract

Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.

Originalsprache	Englisch
Zeitschrift	Antimicrobial Agents and Chemotherapy
Jahrgang	57
Ausgabenummer	6
Seiten (von - bis)	2828-30
Seitenumfang	3
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.02211-12
Publikationsstatus	Veröffentlicht - 06.2013

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10.1128/AAC.02211-12

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abstract = "Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.",

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AU - Rupp, Jan

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AB - Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.

U2 - 10.1128/AAC.02211-12

DO - 10.1128/AAC.02211-12

M3 - Journal articles

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Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia

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