Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

Samer Karamohamed; L. I. Golbe; M. H. Mark; A. M. Lazzarini; O. Suchowersky; N. Labelle; Mark Guttman; L. J. Currie; G. F. Wooten; M. Stacy; M. Saint-Hilaire; R. G. Feldman; J. Liu; C. M. Shoemaker; J. B. Wilk; A. L. DeStefano; J. C. Latourelle; G. Xu; R. Watts; J. Growdon; M. Lew; C. Waters; P. Vieregge; P. P. Pramstaller; C. Klein; B. A. Racette; J. S. Perlmutter; A. Parsian; Carlos Singer; E. Montgomery; K. Baker; J. F. Gusella; A. Herbert; R. H. Myers

doi:10.1002/mds.20515

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

Samer Karamohamed^*, L. I. Golbe, M. H. Mark, A. M. Lazzarini, O. Suchowersky, N. Labelle, Mark Guttman, L. J. Currie, G. F. Wooten, M. Stacy, M. Saint-Hilaire, R. G. Feldman, J. Liu, C. M. Shoemaker, J. B. Wilk, A. L. DeStefano, J. C. Latourelle, G. Xu, R. Watts, J. GrowdonM. Lew, C. Waters, P. Vieregge, P. P. Pramstaller, C. Klein, B. A. Racette, J. S. Perlmutter, A. Parsian, Carlos Singer, E. Montgomery, K. Baker, J. F. Gusella, A. Herbert, R. H. Myers

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Neurogenetik

19 Zitate (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.

Originalsprache	Englisch
Zeitschrift	Movement Disorders
Jahrgang	20
Ausgabenummer	9
Seiten (von - bis)	1188-1191
Seitenumfang	4
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.20515
Publikationsstatus	Veröffentlicht - 01.09.2005

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Karamohamed, S., Golbe, L. I., Mark, M. H., Lazzarini, A. M., Suchowersky, O., Labelle, N., Guttman, M., Currie, L. J., Wooten, G. F., Stacy, M., Saint-Hilaire, M., Feldman, R. G., Liu, J., Shoemaker, C. M., Wilk, J. B., DeStefano, A. L., Latourelle, J. C., Xu, G., Watts, R., ... Myers, R. H. (2005). Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study. Movement Disorders, 20(9), 1188-1191. https://doi.org/10.1002/mds.20515

@article{8305ca120cc248cb8b27ca2ce4749d11,

title = "Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study",

abstract = "Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.",

author = "Samer Karamohamed and Golbe, \{L. I.\} and Mark, \{M. H.\} and Lazzarini, \{A. M.\} and O. Suchowersky and N. Labelle and Mark Guttman and Currie, \{L. J.\} and Wooten, \{G. F.\} and M. Stacy and M. Saint-Hilaire and Feldman, \{R. G.\} and J. Liu and Shoemaker, \{C. M.\} and Wilk, \{J. B.\} and DeStefano, \{A. L.\} and Latourelle, \{J. C.\} and G. Xu and R. Watts and J. Growdon and M. Lew and C. Waters and P. Vieregge and Pramstaller, \{P. P.\} and C. Klein and Racette, \{B. A.\} and Perlmutter, \{J. S.\} and A. Parsian and Carlos Singer and E. Montgomery and K. Baker and Gusella, \{J. F.\} and A. Herbert and Myers, \{R. H.\}",

year = "2005",

month = sep,

day = "1",

doi = "10.1002/mds.20515",

language = "English",

volume = "20",

pages = "1188--1191",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley \& Sons Inc.",

number = "9",

}

Karamohamed, S, Golbe, LI, Mark, MH, Lazzarini, AM, Suchowersky, O, Labelle, N, Guttman, M, Currie, LJ, Wooten, GF, Stacy, M, Saint-Hilaire, M, Feldman, RG, Liu, J, Shoemaker, CM, Wilk, JB, DeStefano, AL, Latourelle, JC, Xu, G, Watts, R, Growdon, J, Lew, M, Waters, C, Vieregge, P, Pramstaller, PP, Klein, C, Racette, BA, Perlmutter, JS, Parsian, A, Singer, C, Montgomery, E, Baker, K, Gusella, JF, Herbert, A & Myers, RH 2005, 'Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study', Movement Disorders, Jg. 20, Nr. 9, S. 1188-1191. https://doi.org/10.1002/mds.20515

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study. / Karamohamed, Samer; Golbe, L. I.; Mark, M. H. et al.
in: Movement Disorders, Jahrgang 20, Nr. 9, 01.09.2005, S. 1188-1191.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

AU - Karamohamed, Samer

AU - Golbe, L. I.

AU - Mark, M. H.

AU - Lazzarini, A. M.

AU - Suchowersky, O.

AU - Labelle, N.

AU - Guttman, Mark

AU - Currie, L. J.

AU - Wooten, G. F.

AU - Stacy, M.

AU - Saint-Hilaire, M.

AU - Feldman, R. G.

AU - Liu, J.

AU - Shoemaker, C. M.

AU - Wilk, J. B.

AU - DeStefano, A. L.

AU - Latourelle, J. C.

AU - Xu, G.

AU - Watts, R.

AU - Growdon, J.

AU - Lew, M.

AU - Waters, C.

AU - Vieregge, P.

AU - Pramstaller, P. P.

AU - Klein, C.

AU - Racette, B. A.

AU - Perlmutter, J. S.

AU - Parsian, A.

AU - Singer, Carlos

AU - Montgomery, E.

AU - Baker, K.

AU - Gusella, J. F.

AU - Herbert, A.

AU - Myers, R. H.

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.

AB - Parkinson's disease (PD) is a neurodegenerative disorder in which relatives of the probands are affected approximately 4 times as frequently as relatives of control subjects. Several genes have been implicated as genetic risk factors for PD. We investigated the presence of six reported genetic variations in the SCNA, NR4A2, and DJ-1 genes in 292 cases of familial Parkinson's disease from the GenePD study. None of the variants were found in the GenePD families. Our results suggest that other variants or genes account for the familial risk of PD within the GenePD study.

UR - https://www.scopus.com/pages/publications/27744440820

U2 - 10.1002/mds.20515

DO - 10.1002/mds.20515

M3 - Journal articles

C2 - 15966003

AN - SCOPUS:27744440820

SN - 0885-3185

VL - 20

SP - 1188

EP - 1191

JO - Movement Disorders

JF - Movement Disorders

IS - 9

ER -

Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study

Abstract

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