TY - GEN
T1 - A Simplified Production Method for Multimode Multisite Neuroprobes
AU - Mankodiya, K.
AU - Krapohl, D.
AU - Hammad, S.
AU - Xie, Y.
AU - Klinger, M.
AU - Hofmann, U. G.
N1 - Conference code: 77536
PY - 2009/4/1
Y1 - 2009/4/1
N2 - Unified electro-optical microprobes for co-localized optical and electrical recordings within a rats brain have been recently introduced (Krapohl, Bonin et al. 2008). In this work, we show a simplified production method for these multimodal multisite neuroprobes. The electro-optical neuroprobe has an outer diameter of 255 mum and is composed of eight NiChrome wires (Oslash 25 mum) fixed to the surface of a mono-mode glass fiber (Oslash 125 mum). Where the former method elaborately braids the wires around the fiber, the new method uses the property of a PTFE tube to shrink at higher temperature (> 300degC). Thus the microwires are pressed to the fiber. The probe tip is than hand polished and is such ready to be used in rat brain navigation experiments, featuring both functions electrical as well as anatomical, optical look-ahead properties. The latter is achieved by using the glass fiber as working probe for an optical coherence tomography (OCT) system. Hence these electrooptical probes are called OCT rodes. We determined the impedance of the OCT rodes by impedance spectroscopy to lie in the range of 500 kOmega at 1 kHz frequency. This range enables them to record both single and multi unit activity. OCT experiments have shown promising results in detecting transversal boundaries between structures of different density in phantoms and cadaver brain. Ongoing experiments aim at co-localized optical and electrical recordings in living animals.
AB - Unified electro-optical microprobes for co-localized optical and electrical recordings within a rats brain have been recently introduced (Krapohl, Bonin et al. 2008). In this work, we show a simplified production method for these multimodal multisite neuroprobes. The electro-optical neuroprobe has an outer diameter of 255 mum and is composed of eight NiChrome wires (Oslash 25 mum) fixed to the surface of a mono-mode glass fiber (Oslash 125 mum). Where the former method elaborately braids the wires around the fiber, the new method uses the property of a PTFE tube to shrink at higher temperature (> 300degC). Thus the microwires are pressed to the fiber. The probe tip is than hand polished and is such ready to be used in rat brain navigation experiments, featuring both functions electrical as well as anatomical, optical look-ahead properties. The latter is achieved by using the glass fiber as working probe for an optical coherence tomography (OCT) system. Hence these electrooptical probes are called OCT rodes. We determined the impedance of the OCT rodes by impedance spectroscopy to lie in the range of 500 kOmega at 1 kHz frequency. This range enables them to record both single and multi unit activity. OCT experiments have shown promising results in detecting transversal boundaries between structures of different density in phantoms and cadaver brain. Ongoing experiments aim at co-localized optical and electrical recordings in living animals.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-70350589428&origin=inward&txGid=c8a0a5d2a3f678eff7c6e3cad0966654
U2 - 10.1109/NER.2009.5109271
DO - 10.1109/NER.2009.5109271
M3 - Conference contribution
SN - 978-1-4244-2072-8
T3 - International IEEE/EMBS Conference on Neural Engineering
SP - 211
EP - 214
BT - 2009 4th International IEEE/EMBS Conference on Neural Engineering
PB - IEEE
T2 - 2009 4th International IEEE/EMBS Conference on Neural Engineering
Y2 - 29 April 2009 through 2 May 2009
ER -