A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Alesia A Miloslavina; Enrico Leipold; Michael Kijas; Annegret Stark; Stefan H Heinemann; Diana Imhof

doi:10.1002/psc.1106

A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Alesia A Miloslavina, Enrico Leipold, Michael Kijas, Annegret Stark, Stefan H Heinemann, Diana Imhof

Klinik für Anästhesiologie und Intensivmedizin

Friedrich-Schiller-Universität Jena

30 Zitate (Scopus)

Abstract

We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

Originalsprache	Englisch
Zeitschrift	Journal of peptide science : an official publication of the European Peptide Society
Jahrgang	15
Ausgabenummer	2
Seiten (von - bis)	72-7
Seitenumfang	6
ISSN	1075-2617
DOIs	https://doi.org/10.1002/psc.1106
Publikationsstatus	Veröffentlicht - 02.2009

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abstract = "We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.",

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A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides. / Miloslavina, Alesia A; Leipold, Enrico; Kijas, Michael et al.
in: Journal of peptide science : an official publication of the European Peptide Society, Jahrgang 15, Nr. 2, 02.2009, S. 72-7.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

AU - Miloslavina, Alesia A

AU - Leipold, Enrico

AU - Kijas, Michael

AU - Stark, Annegret

AU - Heinemann, Stefan H

AU - Imhof, Diana

PY - 2009/2

Y1 - 2009/2

N2 - We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

AB - We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.

U2 - 10.1002/psc.1106

DO - 10.1002/psc.1106

M3 - Journal articles

C2 - 19089803

SN - 1075-2617

VL - 15

SP - 72

EP - 77

JO - Journal of peptide science : an official publication of the European Peptide Society

JF - Journal of peptide science : an official publication of the European Peptide Society

IS - 2

ER -

A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides

Abstract

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