A protein of the endoplasmic reticulum involved early in polypeptide translocation

Dirk Görlich; Enno Hartmann; Siegfried Prehn; Tom A. Rapoport

A protein of the endoplasmic reticulum involved early in polypeptide translocation

Dirk Görlich, Enno Hartmann, Siegfried Prehn, Tom A. Rapoport^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Biologie

205 Zitate (Scopus)

Abstract

To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

Originalsprache	Englisch
Zeitschrift	Nature
Jahrgang	357
Ausgabenummer	6373
Seiten (von - bis)	47-52
Seitenumfang	6
ISSN	0028-0836
Publikationsstatus	Veröffentlicht - 01.12.1992

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title = "A protein of the endoplasmic reticulum involved early in polypeptide translocation",

abstract = "To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.",

author = "Dirk G{\"o}rlich and Enno Hartmann and Siegfried Prehn and Rapoport, {Tom A.}",

year = "1992",

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T1 - A protein of the endoplasmic reticulum involved early in polypeptide translocation

AU - Görlich, Dirk

AU - Hartmann, Enno

AU - Prehn, Siegfried

AU - Rapoport, Tom A.

PY - 1992/12/1

Y1 - 1992/12/1

N2 - To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

AB - To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

UR - http://www.scopus.com/inward/record.url?scp=0026504192&partnerID=8YFLogxK

M3 - Journal articles

C2 - 1315422

AN - SCOPUS:0026504192

SN - 0028-0836

VL - 357

SP - 47

EP - 52

JO - Nature

JF - Nature

IS - 6373

ER -

A protein of the endoplasmic reticulum involved early in polypeptide translocation

Abstract

UN SDGs

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