A Prognostic Tool to Estimate the Risk of Pneumonitis in Patients Irradiated for Lung Cancer

Esther Glatzel, Elisa M. Werner, Sabine Bohnet, Dirk Rades*

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

Background/Aim: Radiotherapy of lung cancer can lead to pneumonitis. This study aimed to identify risk factors and create a prognostic tool. Patients and Methods: Sixteen factors were evaluated in 169 patients irradiated for lung cancer including age, sex, lung function, primary tumor/nodal stage, histology, tumor location, surgery, systemic treatment, radiation volume, total dose, mean dose to ipsilateral lung, history of another malignancy, pack years, chronic inflammatory disease, and cardiovascular disease. Results: Forty-one patients experienced pneumonitis. Significant associations were found for total doses >56 Gy (p=0.023), mean lung doses >20 Gy (p=0.002) or >13 Gy (p<0.001), and chronic inflammatory disease (p=0.034). Considering mean lung dose and chronic inflammatory disease, scores were 2, 3, 4, or 5 points. Pneumonitis rates were 0% (0/35), 24% (14/58), 32% (21/66), and 60% (6/10) (p=0.001), respectively. Conclusion: Based on significant risk factors, a prognostic tool was developed that can help estimate the risk of pneumonitis and contribute to personalized follow up of patients.

OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang42
Ausgabenummer4
Seiten (von - bis)2029-2032
Seitenumfang4
ISSN0250-7005
DOIs
PublikationsstatusVeröffentlicht - 04.2022

Strategische Forschungsbereiche und Zentren

  • Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)
  • Profilbereich: Lübeck Integrated Oncology Network (LION)

Fingerprint

Untersuchen Sie die Forschungsthemen von „A Prognostic Tool to Estimate the Risk of Pneumonitis in Patients Irradiated for Lung Cancer“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren