A potential role for a genetic variation of AKAP5 in human aggression and anger control

Sylvia Richter, Xenia Gorny, Josep Marco-Pallares, Ulrike M. Krämer, Judith Machts, Adriana Barman, Hans Gert Bernstein, Rebecca Schüle, Ludger Schöls, Antoni Rodriguez-Fornells, Carsten Reissner, Torsten Wüstenberg, Hans Jochen Heinze, Eckart D. Gundelfinger, Emrah Düzel, Thomas F. Münte, Constanze I. Seidenbecher, Björn H. Schott

    13 Zitate (Scopus)


    The A-kinase-anchoring protein 5 (AKAP5), a post-synaptic multi-adaptor molecule that binds G-protein-coupled receptors and intracellular signaling molecules has been implicated in emotional processing in rodents, but its role in human emotion and behavior is up to now still not quite clear. Here, we report an association of individual differences in aggressive behavior and anger expression with a functional genetic polymorphism (Pro100Leu) in the human AKAP5 gene. Among a cohort of 527 young, healthy individuals, carriers of the less common Leu allele (15.6% allele frequency) scored significantly lower in the physical aggression domain of the Buss and Perry Aggression Questionnaire and higher in the anger control dimension of the state-trait anger expression inventory. In a functional magnetic resonance imaging experiment we could further demonstrate that AKAP5 Pro100Leu modulates the interaction of negative emotional processing and executive functions. In order to investigate implicit processes of anger control, we used the well-known flanker task to evoke processes of action monitoring and error processing and added task-irrelevant neutral or angry faces in the background of the flanker stimuli. In line with our predictions, Leu carriers showed increased activation of the anterior cingulate cortex (ACC) during emotional interference, which in turn predicted shorter reaction times and might be related to stronger control of emotional interference. Conversely, Pro homozygotes exhibited increased orbitofrontal cortex (OFC) activation during emotional interference, with no behavioral advantage. Immunohistochemistry revealed AKAP5 expression in post mortem human ACC and OFC. Our results suggest that AKAP5 Pro100Leu contributes to individual differences in human aggression and anger control. Further research is warranted to explore the detailed role of AKAP5 and its gene product in human emotion processing.

    ZeitschriftFrontiers in Human Neuroscience
    PublikationsstatusVeröffentlicht - 29.12.2011

    Strategische Forschungsbereiche und Zentren

    • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)


    Untersuchen Sie die Forschungsthemen von „A potential role for a genetic variation of AKAP5 in human aggression and anger control“. Zusammen bilden sie einen einzigartigen Fingerprint.