A platelet-mediated system for shuttling blood-borne bacteria to CD8α + dendritic cells depends on glycoprotein GPIb and complement C3

Admar Verschoor, Michael Neuenhahn, Alexander A. Navarini, Patricia Graef, Ann Plaumann, Amelie Seidlmeier, Bernhard Nieswandt, Steffen Massberg, Rolf M. Zinkernagel, Hans Hengartner, Dirk H. Busch*

*Korrespondierende/r Autor/-in für diese Arbeit
    118 Zitate (Scopus)

    Abstract

    The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8 + T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α + DCs. We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3. Platelet association targeted a small but immunologically important portion of L. monocytogenes to splenic CD8α + DCs, diverting bacteria from swift clearance by other, less immunogenic phagocytes. Thus, an effective balance is established between maintaining sterility of the circulation and induction of antibacterial immunity by DCs. Other Gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria.

    OriginalspracheEnglisch
    ZeitschriftNature Immunology
    Jahrgang12
    Ausgabenummer12
    Seiten (von - bis)1194-1201
    Seitenumfang8
    ISSN1529-2908
    DOIs
    PublikationsstatusVeröffentlicht - 12.2011

    Strategische Forschungsbereiche und Zentren

    • Forschungsschwerpunkt: Infektion und Entzündung - Zentrum für Infektions- und Entzündungsforschung Lübeck (ZIEL)

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