A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer

Neeraj Agarwal; Arun Azad; Joan Carles; Simon Chowdhury; Bradley McGregor; Axel S. Merseburger; Stéphane Oudard; Fred Saad; Andrey Soares; Fawzi Benzaghou; Yannick Kerloeguen; Akiko Kimura; Nehal Mohamed; Ashok Panneerselvam; Fong Wang; Sumanta Pal

doi:10.2217/fon-2021-1096

A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer

Neeraj Agarwal, Arun Azad, Joan Carles, Simon Chowdhury, Bradley McGregor, Axel S. Merseburger, Stéphane Oudard, Fred Saad, Andrey Soares, Fawzi Benzaghou, Yannick Kerloeguen, Akiko Kimura, Nehal Mohamed, Ashok Panneerselvam, Fong Wang, Sumanta Pal

33 Zitate (Scopus)

Abstract

Cabozantinib inhibits multiple receptor tyrosine kinases, including the TAM kinase family, and may enhance response to immune checkpoint inhibitors. One cohort of the ongoing phase Ib COSMIC-021 study (NCT03170960) evaluating cabozantinib plus the PD-L1 inhibitor atezolizumab in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed in soft tissue on/after enzalutamide and/or abiraterone treatment for metastatic disease has shown promising efficacy. Here, we describe the rationale and design of a phase III trial of cabozantinib plus atezolizumab versus a second novel hormone therapy (NHT) in patients who have previously received an NHT for mCRPC, metastatic castration-sensitive PC or nonmetastatic CRPC and have measurable visceral disease and/or extrapelvic adenopathy - a population with a significant unmet need for treatment options. Trial Registration Clinical Trial Registration: NCT04446117 (ClinicalTrials.gov) Registered on 24 June 2020.

Originalsprache	Englisch
Zeitschrift	Future oncology (London, England)
Jahrgang	18
Ausgabenummer	10
Seiten (von - bis)	1185-1198
Seitenumfang	14
ISSN	1479-6694
DOIs	https://doi.org/10.2217/fon-2021-1096
Publikationsstatus	Veröffentlicht - 01.03.2022

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

SDG 3 – Gesundheit und Wohlergehen

Strategische Forschungsbereiche und Zentren

Profilbereich: Lübeck Integrated Oncology Network (LION)

DFG-Fachsystematik

2.22-14 Hämatologie, Onkologie
2.22-23 Reproduktionsmedizin, Urologie
2.22-08 Pharmazie

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10.2217/fon-2021-1096

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Agarwal, N., Azad, A., Carles, J., Chowdhury, S., McGregor, B., Merseburger, A. S., Oudard, S., Saad, F., Soares, A., Benzaghou, F., Kerloeguen, Y., Kimura, A., Mohamed, N., Panneerselvam, A., Wang, F., & Pal, S. (2022). A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer. Future oncology (London, England), 18(10), 1185-1198. https://doi.org/10.2217/fon-2021-1096

@article{ca4614a2383242e58a04449fc17dac39,

title = "A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer",

abstract = "Cabozantinib inhibits multiple receptor tyrosine kinases, including the TAM kinase family, and may enhance response to immune checkpoint inhibitors. One cohort of the ongoing phase Ib COSMIC-021 study (NCT03170960) evaluating cabozantinib plus the PD-L1 inhibitor atezolizumab in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed in soft tissue on/after enzalutamide and/or abiraterone treatment for metastatic disease has shown promising efficacy. Here, we describe the rationale and design of a phase III trial of cabozantinib plus atezolizumab versus a second novel hormone therapy (NHT) in patients who have previously received an NHT for mCRPC, metastatic castration-sensitive PC or nonmetastatic CRPC and have measurable visceral disease and/or extrapelvic adenopathy - a population with a significant unmet need for treatment options. Trial Registration Clinical Trial Registration: NCT04446117 (ClinicalTrials.gov) Registered on 24 June 2020.",

author = "Neeraj Agarwal and Arun Azad and Joan Carles and Simon Chowdhury and Bradley McGregor and Merseburger, \{Axel S.\} and St{\'e}phane Oudard and Fred Saad and Andrey Soares and Fawzi Benzaghou and Yannick Kerloeguen and Akiko Kimura and Nehal Mohamed and Ashok Panneerselvam and Fong Wang and Sumanta Pal",

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year = "2022",

month = mar,

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doi = "10.2217/fon-2021-1096",

language = "English",

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Agarwal, N, Azad, A, Carles, J, Chowdhury, S, McGregor, B, Merseburger, AS, Oudard, S, Saad, F, Soares, A, Benzaghou, F, Kerloeguen, Y, Kimura, A, Mohamed, N, Panneerselvam, A, Wang, F & Pal, S 2022, 'A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer', Future oncology (London, England), Jg. 18, Nr. 10, S. 1185-1198. https://doi.org/10.2217/fon-2021-1096

A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer. / Agarwal, Neeraj; Azad, Arun; Carles, Joan et al.
in: Future oncology (London, England), Jahrgang 18, Nr. 10, 01.03.2022, S. 1185-1198.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer

AU - Agarwal, Neeraj

AU - Azad, Arun

AU - Carles, Joan

AU - Chowdhury, Simon

AU - McGregor, Bradley

AU - Merseburger, Axel S.

AU - Oudard, Stéphane

AU - Saad, Fred

AU - Soares, Andrey

AU - Benzaghou, Fawzi

AU - Kerloeguen, Yannick

AU - Kimura, Akiko

AU - Mohamed, Nehal

AU - Panneerselvam, Ashok

AU - Wang, Fong

AU - Pal, Sumanta

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Cabozantinib inhibits multiple receptor tyrosine kinases, including the TAM kinase family, and may enhance response to immune checkpoint inhibitors. One cohort of the ongoing phase Ib COSMIC-021 study (NCT03170960) evaluating cabozantinib plus the PD-L1 inhibitor atezolizumab in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed in soft tissue on/after enzalutamide and/or abiraterone treatment for metastatic disease has shown promising efficacy. Here, we describe the rationale and design of a phase III trial of cabozantinib plus atezolizumab versus a second novel hormone therapy (NHT) in patients who have previously received an NHT for mCRPC, metastatic castration-sensitive PC or nonmetastatic CRPC and have measurable visceral disease and/or extrapelvic adenopathy - a population with a significant unmet need for treatment options. Trial Registration Clinical Trial Registration: NCT04446117 (ClinicalTrials.gov) Registered on 24 June 2020.

AB - Cabozantinib inhibits multiple receptor tyrosine kinases, including the TAM kinase family, and may enhance response to immune checkpoint inhibitors. One cohort of the ongoing phase Ib COSMIC-021 study (NCT03170960) evaluating cabozantinib plus the PD-L1 inhibitor atezolizumab in men with metastatic castration-resistant prostate cancer (mCRPC) that has progressed in soft tissue on/after enzalutamide and/or abiraterone treatment for metastatic disease has shown promising efficacy. Here, we describe the rationale and design of a phase III trial of cabozantinib plus atezolizumab versus a second novel hormone therapy (NHT) in patients who have previously received an NHT for mCRPC, metastatic castration-sensitive PC or nonmetastatic CRPC and have measurable visceral disease and/or extrapelvic adenopathy - a population with a significant unmet need for treatment options. Trial Registration Clinical Trial Registration: NCT04446117 (ClinicalTrials.gov) Registered on 24 June 2020.

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UR - https://www.mendeley.com/catalogue/50c64964-d16d-3d61-b276-6b145a9f47f8/

U2 - 10.2217/fon-2021-1096

DO - 10.2217/fon-2021-1096

M3 - Journal articles

C2 - 35034502

AN - SCOPUS:85126490290

SN - 1479-6694

VL - 18

SP - 1185

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JO - Future oncology (London, England)

JF - Future oncology (London, England)

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