A New Predictive Tool for Optimization of the Treatment of Brain Metastases from Colorectal Cancer After Stereotactic Radiosurgery

Dirk Rades, Markus Dahlke, Niklas Gebauer, Tobias Bartscht, Dagmar Hornung, Ngo Thuy Trang, Pham Cam Phuong, Mai Trong Khoa, Jan Gliemroth

Abstract

AIM: To develop a predictive tool for survival after stereotactic radiosurgery of brain metastases from colorectal cancer. PATIENTS AND METHODS: Out of nine factors analyzed for survival, those showing significance (p<0.05) or a trend (p≤0.06) were included. For each factor, 0 (worse survival) or 1 (better survival) point was assigned. Total scores represented the sum of the factor scores. RESULTS: Performance status (p=0.010) and interval from diagnosis of colorectal cancer until radiosurgery (p=0.026) achieved significance, extracranial metastases showed a trend (p=0.06). These factors were included in the tool. Total scores were 0-3 points. Six-month survival rates were 17% for patients with 0, 25% for those with 1, 67% for those with 2 and 100% for those with 3 points; 12-month rates were 0%, 0%, 33% and 67%, respectively. Two groups were created: 0-1 and 2-3 points. Six- and 12-month survival rates were 20% vs. 78% and 0% vs. 44% (p=0.002), respectively. CONCLUSION: This tool helps optimize the treatment of patients after stereotactic radiosurgery for brain metastases from colorectal cancer.
OriginalspracheEnglisch
ZeitschriftAnticancer Research
Jahrgang35
Ausgabenummer10
Seiten (von - bis)5515-8
Seitenumfang4
ISSN0250-7005
PublikationsstatusVeröffentlicht - 2015

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