A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz; Wolfgang Jelkmann; Christian Bauer

doi:10.1016/0014-5793(82)81081-8

A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz^*, Wolfgang Jelkmann, Christian Bauer

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Physiologie

Universität Regensburg

66 Zitate (Scopus)

Abstract

The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

Originalsprache	Englisch
Zeitschrift	FEBS Letters
Jahrgang	149
Ausgabenummer	1
Seiten (von - bis)	105-108
Seitenumfang	4
ISSN	0014-5793
DOIs	https://doi.org/10.1016/0014-5793(82)81081-8
Publikationsstatus	Veröffentlicht - 22.11.1982

Fördermittel

Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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title = "A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I",

abstract = "The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.",

author = "Armin Kurtz and Wolfgang Jelkmann and Christian Bauer",

note = "Funding Information: Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1982",

month = nov,

day = "22",

doi = "10.1016/0014-5793(82)81081-8",

language = "English",

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T1 - A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

AU - Kurtz, Armin

AU - Jelkmann, Wolfgang

AU - Bauer, Christian

N1 - Funding Information: Our sincere thanks are to Professor E.R. Froesch for supplyingu s with IGF I. This work was financially supported by the Sonderfor-schungsbereich4 3 of the DeutscheF orschungs-gemeinscha.f t Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1982/11/22

Y1 - 1982/11/22

N2 - The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

AB - The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

UR - https://www.scopus.com/pages/publications/0020393390

U2 - 10.1016/0014-5793(82)81081-8

DO - 10.1016/0014-5793(82)81081-8

M3 - Journal articles

C2 - 6759171

AN - SCOPUS:0020393390

SN - 0014-5793

VL - 149

SP - 105

EP - 108

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Abstract

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