A new candidate for the regulation of erythropoiesis. Insulin-like growth factor I

Armin Kurtz*, Wolfgang Jelkmann, Christian Bauer

*Korrespondierende/r Autor/-in für diese Arbeit
58 Zitate (Scopus)

Abstract

The effect of pure human insulin-like growth factor I (IGF I) on the colony formation of late stage erythroid precursor cells (CFU-e) from fetal mouse liver and adult bone marrow was studied in a serum-free culture system. We found that IGF I in physiological concentrations stimulated erythroid colony formation. The combined effect of IGF I and erythropoietin was smaller than the sum of their single effects. The number of colonies induced by IGF I was linearly dependent on the number of plated cells. Our results indicate that IGF I is the first early defined mitogen that stimulates the late stages of erythroid differentiation independently of erythropoietin.

OriginalspracheEnglisch
ZeitschriftFEBS Letters
Jahrgang149
Ausgabenummer1
Seiten (von - bis)105-108
Seitenumfang4
ISSN0014-5793
DOIs
PublikationsstatusVeröffentlicht - 22.11.1982

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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