A Narrative Review - Therapy Options and Therapy Failure in Retinoblastoma

Argyrios Chronopoulos, Neele Babst, Christian Schiemenz, James S. Schutz, Ludwig M. Heindl, Mahdy Ranjbar, Vinodh Kakkassery

3 Zitate (Scopus)

Abstract

Retinoblastoma (RB) management has evolved over the last three decades. Goals of modern RB treatment are first to protect life and prevent metastatic disease, then preservation of the globe and useful vision. With modern treatment protocols and early disease detection success rates can reach up to 100% of disease-free-globe and eye preservation. Treatment of advanced cases remains complex, requiring aggressive chemotherapy or/and external beam radiation. Treatment protocols are extremely diverse and dependent on local resources thus success rates are variable. Here we review narratively current treatment protocols and failure rates based on a PubMed search using keywords of retinoblastoma, retinoblastoma seed, retinoblastoma treatment, enucleation.

OriginalspracheEnglisch
ZeitschriftNeuroSignals
Jahrgang30
Seiten (von - bis)39-58
Seitenumfang20
ISSN1424-862X
DOIs
PublikationsstatusVeröffentlicht - 2022

Strategische Forschungsbereiche und Zentren

  • Profilbereich: Lübeck Integrated Oncology Network (LION)
  • Zentren: Universitäres Cancer Center Schleswig-Holstein (UCCSH)

DFG-Fachsystematik

  • 205-14 Hämatologie, Onkologie
  • 206-11 Augenheilkunde

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