A long-term cost-effectiveness analysis of cardiac resynchronisation therapy with or without defibrillator based on health claims data

Moritz Hadwiger, Laura Schumann, Nora Eisemann, Nikolaos Dagres, Gerhard Hindricks, Janina Haug, Michael Wolf, Ursula Marschall, Alexander Katalinic, Fabian-Simon Frielitz

Abstract

BACKGROUND: In Germany, CRT devices with defibrillator capability (CRT-D) have become the predominant treatment strategy for patients with heart failure and cardiac dyssynchrony. However, according to current guidelines, most patients would also be eligible for the less expensive CRT pacemaker (CRT-P). We conducted a cost-effectiveness analysis for CRT-P devices compared to CRT-D devices from a German payer's perspective. METHODS: Longitudinal health claims data from 3569 patients with de novo CRT implantation from 2014 to 2019 were used to parametrise a cohort Markov model. Model outcomes were costs and effectiveness measured in terms of life years. Transition probabilities were derived from multivariable parametric survival regression that controlled for baseline differences of CRT-D and CRT-P patients. Deterministic and probabilistic sensitivity analyses were conducted. RESULTS: The Markov model predicted a median survival of 84 months for CRT-P patients and 92 months for CRT-D patients. In the base case, CRT-P devices incurred incremental costs of € - 13,093 per patient and 0.30 incremental life years were lost. The ICER was € 43,965 saved per life year lost. In the probabilistic sensitivity analysis, uncertainty regarding the effectiveness was observed but not regarding costs. CONCLUSION: This modelling study illustrates the uncertainty of the higher effectiveness of CRT-D devices compared to CRT-P devices. Given the difference in incremental costs between CRT-P and CRT-D treatment, there would be significant potential cost savings to the healthcare system if CRT-D devices were restricted to patients likely to benefit from the additional defibrillator.
OriginalspracheEnglisch
Aufsatznummer48
ZeitschriftCost effectiveness and resource allocation : C/E
Jahrgang20
Ausgabenummer1
ISSN1478-7547
DOIs
PublikationsstatusVeröffentlicht - 02.09.2022

Strategische Forschungsbereiche und Zentren

  • Profilbereich: Zentrum für Bevölkerungsmedizin und Versorgungsforschung (ZBV)

Fingerprint

Untersuchen Sie die Forschungsthemen von „A long-term cost-effectiveness analysis of cardiac resynchronisation therapy with or without defibrillator based on health claims data“. Zusammen bilden sie einen einzigartigen Fingerprint.

Zitieren