A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells

Muhammad Mushtaq, Rizwan ul Haq, Waqas Anwar, Lisa Marshall, Maxim Bazhenov, Kashif Zia, Hina Alam, Lars Hertel, Abdul Aleem Awan, Thomas Martinetz*

*Korrespondierende/r Autor/-in für diese Arbeit

Abstract

The hippocampus plays a key role in memory formation and learning. According to the concept of active systems memory consolidation, transiently stored memory traces are transferred from the hippocampus into the neocortex for permanent storage. This phenomenon relies on hippocampal network oscillations, particularly sharp wave ripples [SPW-Rs). In this process prior saved data in the hippocampus may be reactivated. Recent investigations reveal that several neurotransmitters and neuromodulators including norepinephrine, acetylcholine, serotonin, etc., suppress SPW-Rs activity in rodents’ hippocampal slices. This suppression of SPW-Rs may depend on various presynaptic and postsynaptic parameters including decrease in calcium influx, hyperpolarization/depolarization and alteration in gap junctions’ function in pyramidal cells. In this study, we demonstrate the impact of calcium influx and gap junctions on pyramidal cells for the modulation of SPW-Rs in a computational model of CA1. We used,SPW-Rs model with some modifications. SPW-Rs are simulated with gradual reduction of calcium and with decreasing conductance through gap junctions in PCs. Both, with calcium reduction as well as with conductance reduction through gap junctions, SPW-Rs are suppressed. Both effects add up synergistically in combination.

OriginalspracheEnglisch
ZeitschriftBioengineered
Jahrgang12
Ausgabenummer1
Seiten (von - bis)2603-2615
Seitenumfang13
ISSN2165-5979
DOIs
PublikationsstatusVeröffentlicht - 12.2021

Strategische Forschungsbereiche und Zentren

  • Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)
  • Querschnittsbereich: Intelligente Systeme
  • Zentren: Zentrum für Künstliche Intelligenz Lübeck (ZKIL)

DFG-Fachsystematik

  • 201-07 Bioinformatik und Theoretische Biologie

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