48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

H. Gann; D. Riemann; F. Hohagen; L. G. Strauss; H. Dressing; W. E. Müller; M. Berger

doi:10.1016/0165-0327(93)90042-I

48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

H. Gann, D. Riemann, F. Hohagen, L. G. Strauss, H. Dressing, W. E. Müller, M. Berger

Klinik für Psychiatrie und Psychotherapie

Universität Mannheim

20 Zitate (Scopus)

Abstract

We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT₄.

Originalsprache	Englisch
Zeitschrift	Journal of Affective Disorders
Jahrgang	28
Ausgabenummer	2
Seiten (von - bis)	133-140
Seitenumfang	8
ISSN	0165-0327
DOIs	https://doi.org/10.1016/0165-0327(93)90042-I
Publikationsstatus	Veröffentlicht - 06.1993

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Forschungsschwerpunkt: Gehirn, Hormone, Verhalten - Center for Brain, Behavior and Metabolism (CBBM)

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@article{c9effd892e134698a228ee4f256c1690,

title = "48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case",

abstract = "We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.",

author = "H. Gann and D. Riemann and F. Hohagen and Strauss, {L. G.} and H. Dressing and M{\"u}ller, {W. E.} and M. Berger",

note = "Funding Information: This study was supported by a grant from the DFG (SFB 258, Al).",

year = "1993",

month = jun,

doi = "10.1016/0165-0327(93)90042-I",

language = "English",

volume = "28",

pages = "133--140",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

number = "2",

}

48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case. / Gann, H.; Riemann, D.; Hohagen, F. et al.
in: Journal of Affective Disorders, Jahrgang 28, Nr. 2, 06.1993, S. 133-140.

Publikation: Beiträge in Fachzeitschriften › Zeitschriftenaufsätze › Forschung › Begutachtung

TY - JOUR

T1 - 48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

AU - Gann, H.

AU - Riemann, D.

AU - Hohagen, F.

AU - Strauss, L. G.

AU - Dressing, H.

AU - Müller, W. E.

AU - Berger, M.

N1 - Funding Information: This study was supported by a grant from the DFG (SFB 258, Al).

PY - 1993/6

Y1 - 1993/6

N2 - We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.

AB - We report a 64-year-old patient suffering from rapid cycling bipolar disorder who was studied by means of polysomnography, neuroendocrine tests and PET (position emission tomography) imaging. In a manner only partly compatible with the cholinergic-aminergic imbalance model of mania and depression, a linkage of REM sleep disinhibition and depressive mood was observed, but no decisive REM sleep delay was seen on manic days. Growth hormone secretion after clonidine stimulation was blunted on depressive and hypomanic days. A series of total sleep deprivations led to a postive effect on psychopathology for about two weeks. Carbamazepine treatment normalized REM sleep variables, damped the amplitude of mood cycling of the patient, increased TSH and decreased FT4.

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U2 - 10.1016/0165-0327(93)90042-I

DO - 10.1016/0165-0327(93)90042-I

M3 - Journal articles

C2 - 8354769

AN - SCOPUS:0027253193

SN - 0165-0327

VL - 28

SP - 133

EP - 140

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 2

ER -

48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case

Abstract

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